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Article

Identification of SMARCAL1 as a component of the DNA damage response.

The Journal of biological chemistry - 18 Dec 2009

Postow Lisa, Woo Eileen M, Chait Brian T, Funabiki Hironori

Abstract excerpt

SMARCAL1 (also known as HARP) is a SWI/SNF family protein with an ATPase activity stimulated by DNA containing both single-stranded and double-stranded regions. Mutations in SMARCAL1 are associated with the disease Schimke immuno-osseous dysplasia, a multisystem autosomal recessive disorder characterized by T cell immunodeficiency, growth inhibition, and renal dysfunction. The cellular function of SMARCAL1,...

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Topics

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Share to Abnormalities, Multiple
Share to DNA Breaks, Double-Stranded
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19841479
DOI: 10.1074/jbc.M109.048330
PMCID: PMC2791023

Genes

SMARCAL1
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification of SMARCAL1 as a component of the DNA damage response.PMID 19841479Read ↗

The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks.Semantic proximity Read ↗

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SMARCAL1, the annealing helicase and the transcriptional co-regulator.Semantic proximity Read ↗

Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability.Semantic proximity Read ↗

Defective replication stress response inhibits lymphomagenesis and impairs lymphocyte reconstitution.Semantic proximity Read ↗

Ligand-induced conformation changes drive ATP hydrolysis and function in SMARCAL1.Semantic proximity Read ↗

Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity.Semantic proximity Read ↗

Deficiency of smarcal1 causes cell cycle arrest and developmental abnormalities in zebrafish.Semantic proximity Read ↗

On the Interaction Between SMARCAL1 and BRG1Semantic proximity Read ↗

The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1.Semantic proximity Read ↗

NSMF promotes the replication stress-induced DNA damage response for genome maintenanceSemantic proximity Read ↗

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