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Article

Cis lethal genetic interactions attenuate and alter p53 tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2010

Wang Yuxun, Zhang Weijia, Edelmann Lisa, Kolodner Richard D, Kucherlapati Raju, Edelmann Winfried

Abstract excerpt

Rpa1, an essential gene involved in DNA replication and genome maintenance, is syntenic and linked to Trp53 in mice and humans. To study the genetic interaction between Rpa1 and Trp53 in tumorigenesis, we generated compound Rpa1(L230P/+); Trp53(+/-) mutant mice with the mutant alleles in either t...

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Share to Epistasis, Genetic
Share to Genes, p53
Share to Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Loss of Heterozygosity

Share to Mice, Mutant Strains

Share to Neoplasms, Experimental

Share to Replication Protein A

Source

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Identifiers

PMID: 20212136
DOI: 10.1073/pnas.1001223107
PMCID: PMC2851751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20212136-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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