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Increased oxidative damage with altered antioxidative status in type 2 diabetic patients harboring the 16189 T to C variant of mitochondrial DNA.

Annals of the New York Academy of Sciences - 1 May 2005

Lin Tsu-Kung, Chen Shang-Der, Wang Pei-Wen, Wei Yau-Huei, Lee Cheng-Feng, Chen Tzu-Ling, Chuang Yao-Chung, Tan Teng-Yeow, Chang Ku-Chou, Liou Chia-Wei

Abstract excerpt

A transition of T to C at nucleotide position 16189 in mitochondrial DNA (mtDNA) has attracted biomedical researchers for its probable correlation with the development of diabetes mellitus in adult life. In diabetes, persistent hyperglycemia may cause high production of free radicals. Reactive oxygen species are thought to play a role in a variety of physiologic and pathophysiologic processes in which increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15965046
DOI: 10.1196/annals.1338.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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