Article
Single nucleotide polymorphisms in the mitochondrial control region are associated with metabolic phenotypes and oxidative stress.
Gene - 1 Dec 2013
Weng Shao-Wen, Lin Tsu-Kung, Wang Pei-Wen, Chen Shang-Der, Chuang Yao-Chung, Liou Chia-Wei
Abstract excerpt
OBJECTIVE: To identify the mitochondrial DNA (mtDNA) single nucleotide polymorphisms (SNPs) in the control region and elucidate their role in metabolic phenotypes and oxidative stress. METHODS: A total of 861 nondiabetic subjects were enrolled, including 250 impaired fasting glucose (IFG) and 370 obese subjects (body mass index [BMI]>25 kg/m(2)). Antioxidant status presented as total free thiol level was...
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