Article
The Role of Oxidative Stress in Diabetic Neuropathy: Generation of Free Radical Species in the Glycation Reaction and Gene Polymorphisms Encoding Antioxidant Enzymes to Genetic Susceptibility to Diabetic Neuropathy in Population of Type I Diabetic Patients.
Cell biochemistry and biophysics - 1 Apr 2015
Babizhayev Mark A, Strokov Igor A, Nosikov Valery V, Savel'yeva Ekaterina L, Sitnikov Vladimir F, Yegorov Yegor E, Lankin Vadim Z
Abstract excerpt
Diabetic neuropathy (DN) represents the main cause of morbidity and mortality among diabetic patients. Clinical data support the conclusion that the severity of DN is related to the frequency and duration of hyperglycemic periods. The presented experimental and clinical evidences propose that changes in cellular function resulting in oxidative stress act as a leading factor in the development and progression of...
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