Article
Low antioxidant content and mutation load in mitochondrial DNA A3243G mutation-related diabetes mellitus.
Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Aug 2003
Liou Chia-Wei, Huang Chin-Chang, Lee Cheng-Feng, Lin Tsu-Kung, Wei Yau-Huei
Abstract excerpt
BACKGROUND AND PURPOSE: Diabetes mellitus (DM) is a common clinical manifestation in patients harboring mitochondrial encephalomyopathy, lactic acidosis with stroke-like episodes (MELAS)-specific A3243G mitochondrial DNA (mtDNA) mutation. However, in some MELAS family members, the presence of mtDNA mutation in the blood is not always associated with DM, and the relationship between development of DM and A3243G...
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