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Mitochondrial ND1 T4216C and ND2 C5178A mutations are associated with maternally transmitted diabetes mellitus.

Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis - 1 Mar 2021

Jiang Zhaochang, Teng Lili, Zhang Shunrong, Ding Yu

Abstract excerpt

Mutations in mitochondrial DNA (mtDNA) are important causes for type 2 diabetes mellitus (T2DM). To investigate the association between mtDNA mutations/variants and diabetes, we reported here clinical, genetic and biochemical characterization of a Chinese pedigree with maternally transmitted T2DM. Using PCR and direct sequencing analysis of mitochondrial genomes from the matrilineal relatives, we identified two...

Topics

DNA, Mitochondrial
Diabetes Mellitus, Type 2
Genome, Mitochondrial
Humans
Maternal Inheritance
Mitochondria
Mutation
NADH Dehydrogenase

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33284036
DOI: 10.1080/24701394.2020.1856101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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