Article

Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A

2019-11-25

Abstract excerpt

<h4>ABSTRACT</h4> Human lysine demethylase KDM5A is a chromatin modifying enzyme associated with transcriptional regulation due to its ability to catalyze removal of methyl groups from methylated lysine 4 of histone H3 (H3K4me3). Amplification of KDM5A is observed in a number of cancers, including breast cancer, prostate cancer, hepatocellular carcinoma, lung cancer and gastric cancer. In this study, we employed...

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Literature Corpus work: bbadfbab-067c-523f-93ce-e5a47a4dbba2
DOI: 10.1101/854265

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