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Article

Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays.

Chemistry & biology - 1 Jan 2008

Rathert Philipp, Zhang Xing, Freund Christian, Cheng Xiaodong, Jeltsch Albert

Abstract excerpt

Histone methylation is an epigenetic mark essential for gene regulation and development. We introduce peptide SPOT synthesis to study sequence specificity of the Dim-5 histone-3 lysine-9 methyltransferase. Dim-5 recognizes R8-G12 of the H3 tail with T11 and G12 being the most important specificit...

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Identifiers

PMID: 18215768
DOI: 10.1016/j.chembiol.2007.11.013
PMCID: PMC2723807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18215768-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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