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Article

Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays.

Chemistry & biology - 1 Jan 2008

Rathert Philipp, Zhang Xing, Freund Christian, Cheng Xiaodong, Jeltsch Albert

Abstract excerpt

Histone methylation is an epigenetic mark essential for gene regulation and development. We introduce peptide SPOT synthesis to study sequence specificity of the Dim-5 histone-3 lysine-9 methyltransferase. Dim-5 recognizes R8-G12 of the H3 tail with T11 and G12 being the most important specificity determinants. Exchange of H3 tail residue S10 and T11 by E strongly reduced methylation by Dim-5, suggesting that...

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Identifiers

PMID: 18215768
DOI: 10.1016/j.chembiol.2007.11.013
PMCID: PMC2723807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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