Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs.

Molecular and cellular biology - 1 Jul 2005

Hyun Joogyung, Jasper Heinrich, Bohmann Dirk

Abstract excerpt

Based on overexpression studies and target gene analyses, the transcription factor DNA replication-related element factor (DREF) has been proposed to regulate growth and replication in Drosophila melanogaster. Here we present loss-of-function experiments to analyze the contribution of DREF to these processes. RNA interference-mediated extinction of DREF function in vivo demonstrates a requirement for the protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Cell Cycle
Share to Genes, Insect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insect Proteins

Share to Organ Size

Share to RNA Interference

Share to S Phase

Share to Wings, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 15964814
DOI: 10.1128/MCB.25.13.5590-5598.2005
PMCID: PMC1157005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs.PMID 15964814Read ↗

Over-expression of DREF in the Drosophila wing imaginal disc induces apoptosis and a notching wing phenotype.Semantic proximity Read ↗

Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and trithorax group proteins.Semantic proximity Read ↗

Role of DREF in transcriptional regulation of the Drosophila p53 gene.Semantic proximity Read ↗

Identification of the Drosophila eIF4A gene as a target of the DREF transcription factor.Semantic proximity Read ↗

dDP is needed for normal cell proliferation.Semantic proximity Read ↗

dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.Semantic proximity Read ↗

Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye.Semantic proximity Read ↗

dE2F2-independent rescue of proliferation in cells lacking an activator dE2F1.Semantic proximity Read ↗

Drosophila distal-less negatively regulates dDREF by inhibiting its DNA binding activity.Semantic proximity Read ↗

Transcriptional regulation of the Drosophila moira and osa genes by the DREF pathway.Semantic proximity Read ↗

Functional antagonism between E2F family members.Semantic proximity Read ↗

Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.