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Article

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.

Genes & development - 1 Apr 2002

Hitoshi Seiji, Alexson Tania, Tropepe Vincent, Donoviel Dorit, Elia Andrew J, Nye Jeffrey S, Conlon Ronald A, Mak Tak W, Bernstein Alan, van der Kooy Derek

Abstract excerpt

Neural stem cells, which exhibit self-renewal and multipotentiality, are generated in early embryonic brains and maintained throughout the lifespan. The mechanisms of their generation and maintenance are largely unknown. Here, we show that neural stem cells are generated independent of RBP-Jkappa, a key molecule in Notch signaling, by using RBP-Jkappa(-/-) embryonic stem cells in an embryonic stem cell-derived...

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Identifiers

PMID: 11937492
DOI: 10.1101/gad.975202
PMCID: PMC186324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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