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Article

AF5, a CNS cell line immortalized with an N-terminal fragment of SV40 large T: growth, differentiation, genetic stability, and gene expression.

Experimental neurology - 1 Jun 2002

Truckenmiller M E, Vawter Marquis P, Zhang Peisu, Conejero-Goldberg Concha, Dillon-Carter Ora, Morales Nelly, Cheadle Chris, Becker Kevin G, Freed William J

Abstract excerpt

Central nervous system progenitor cells that are self-renewing in culture and also differentiate under controlled conditions are potentially useful for developmental studies and for cell-based therapies. We characterized growth and plasticity properties and gene expression in a rat mesencephalic cell line, AF5, that was immortalized with an N-terminal fragment of SV40 large T (T155g). For over 150 population...

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PMID: 12061863
DOI: 10.1006/exnr.2002.7898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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