Article

The temporal balance between self-renewal and differentiation of human neural stem cells requires the Amyloid Precursor Protein

2021-02-17

Abstract excerpt

The approximately 16 billion neurons of the human neocortex are derived from a relatively limited number of developmental neural stem cells (NSCs). During embryogenesis, human cortical NSCs initially generate neurons at a particularly slow rate while preserving their progenitor state for a relatively long time. How this balance between the progenitor state and neurogenic state is regulated, and whether it contribu...

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Literature Corpus work: 99ff5a27-2bb5-5066-a98c-f72e95ac06e5
DOI: 10.1101/2021.02.17.431707

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