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Article

Dexamethasone as a probe for vinorelbine clearance.

British journal of clinical pharmacology - 1 Jul 2005

Puisset Florent, Dalenc Florence, Chatelut Etienne, Cresteil Thierry, Lochon Isabelle, Tisnes Pierre, Roché Henri

Abstract excerpt

AIM: To assess the value of using dexamethasone as an in vivo probe for predicting vinorelbine clearance (CL). METHODS: A population approach (implemented with NONMEM) was used to analyse blood vinorelbine pharmacokinetic data from 20 patients who received a 20-min intravenous infusion of vinorelbine (from 20 to 30 mg m(-2)). Selected patient clinical data as well as known functional single CYP3A5 and ABCB1...

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Source

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Identifiers

PMID: 15963093
DOI: 10.1111/j.1365-2125.2005.02384.x
PMCID: PMC1884916

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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