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Article

Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jun 2006

Wong Mark, Balleine Rosemary L, Blair Elaine Y L, McLachlan Andrew J, Ackland Stephen P, Garg Madhu B, Evans Scott, Farlow David, Collins Michael, Rivory Laurent P, Hoskins Janelle M, Mann Graham J, Clarke Christine L, Gurney Howard

Abstract excerpt

PURPOSE: Marked interindividual variation in drug disposition and toxicity pose an ongoing challenge to chemotherapy dosage individualization. The aim of this study was to evaluate pretreatment clinical features, genotype and functional indicators of drug clearance as predictors of vinorelbine clearance, and myelotoxicity that could inform dosage optimization. PATIENTS AND METHODS: Forty-one patients with cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16651648
DOI: 10.1200/JCO.2005.02.1295

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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