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Article

Impact of pharmacogenetics on variability in exposure to oral vinorelbine among pediatric patients: a model-based population pharmacokinetic analysis.

Cancer chemotherapy and pharmacology - 1 Jul 2022

Hamimed Mourad, Leblond Pierre, Dumont Aurélie, Gattacceca Florence, Tresch-Bruneel Emmanuelle, Probst Alicia, Chastagner Pascal, Pagnier Anne, De Carli Emilie, Entz-Werlé Natacha, Grill Jacques, Aerts Isabelle, Frappaz Didier, Bertozzi-Salamon Anne-Isabelle, Solas Caroline, André Nicolas, Ciccolini Joseph

Abstract excerpt

PURPOSE: Better understanding of pharmacokinetics of oral vinorelbine (VNR) in children would help predicting drug exposure and, beyond, clinical outcome. Here, we have characterized the population pharmacokinetics of oral VNR and studied the factors likely to explain the variability observed in VNR exposure among young patients. DESIGN/METHODS: We collected blood samples from 36 patients (mean age 11.6 years) of...

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PMID: 35751658
DOI: 10.1007/s00280-022-04446-y

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