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Influence of CYP3A5 and ABCB1 polymorphisms on the pharmacokinetics of vincristine in adult patients receiving CHOP therapy.

Cancer chemotherapy and pharmacology - 1 Nov 2023

Nakagawa Junichi, Takahata Takenori, Chen Yu, Saito Kensuke, Kamata Kosuke, Tachita Takuto, Yamashita Satoru, Saito Keigo, Ueno Kayo, Sato Atsushi, Sakuraba Hirotake, Niioka Takenori

Abstract excerpt

PURPOSE: This study aims to clarify the impact of CYP3A5 and ABCB1 polymorphisms on the pharmacokinetics of vincristine (VCR) in adult patients receiving CHOP therapy. METHODS: Plasma samples were collected immediately after the end of VCR administration and at 1.5, 2.5, 3.5, 5.5, 9.5, 13.5, and 25.5 h after the start of administration. Areas under the plasma concentration-time curves of VCR in the elimination...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37610625
DOI: 10.1007/s00280-023-04580-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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