Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developmental pharmacokinetics of etoposide in 67 children: lack of dexamethasone effect.

Cancer chemotherapy and pharmacology - 1 Mar 2011

Urien Saik, Doz François, Giraud Carole, Rey Elisabeth, Gentet Jean-Claude, Chastagner Pascal, Vassal Gilles, Corradini Nadège, Auvrignon Anne, Leblond Pierre, Rubie Hervé, Treluyer Jean-Marc

Abstract excerpt

PURPOSE: A randomized clinical trial examined whether dexamethasone administration prior to ondansetron followed by etoposide and carboplatin infusions, and single-nucleotide polymorphisms (SNPs) of CYP3A4, CYP3A5 and MDR1 genes could modify etoposide pharmacokinetics in pediatric patients. METHODS: Patients, 67 children, aged 14 weeks to 16.7 years, were treated for various malignancies and received either 3- or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carboplatin

Share to Cytochrome P-450 CYP3A

Share to Dexamethasone

Share to Drug Interactions

Share to Etoposide

Share to Nonlinear Dynamics

Source

Identifiers

PMID: 20490798
DOI: 10.1007/s00280-010-1357-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developmental pharmacokinetics of etoposide in 67 children: lack of dexamethasone effect.PMID 20490798Read ↗

Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and ResponseSemantic proximity Read ↗

Characterisation of the clinical pharmacokinetics of actinomycin D and the influence of ABCB1 pharmacogenetic variation on actinomycin D disposition in children with cancer.Semantic proximity Read ↗

Population pharmacokinetics and pharmacogenetics of vincristine in paediatric patients treated for solid tumour diseases.Semantic proximity Read ↗

Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia.Semantic proximity Read ↗

Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL.Semantic proximity Read ↗

Vincristine pharmacodynamics and pharmacogenetics in children with cancer: a limited-sampling, population modelling approach.Semantic proximity Read ↗

The role of solute carrier (SLC) transporters in actinomycin D pharmacokinetics in paediatric cancer patients.Semantic proximity Read ↗

Pharmacogenetic and Clinical Predictors of Ondansetron Failure in a Diverse Pediatric Oncology PopulationSemantic proximity Read ↗

Population Pharmacokinetic Analysis of Dexmedetomidine in Children using Real World Data from Electronic Health Records and Remnant SpecimensSemantic proximity Read ↗

Population analysis of erlotinib in adults and children reveals pharmacokinetic characteristics as the main factor explaining tolerance particularities in children.Semantic proximity Read ↗

Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant.Semantic proximity Read ↗

Escitalopram and Sertraline Population Pharmacokinetic Analysis in Pediatric Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.