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Article

Structural determinants of P-glycoprotein-mediated transport of glucocorticoids.

Pharmaceutical research - 1 Nov 2003

Yates Charles R, Chang Cheng, Kearbey Jeffrey D, Yasuda Kazuto, Schuetz Erin G, Miller Duane D, Dalton James T, Swaan Peter W

Abstract excerpt

PURPOSE: The aim of this study was to determine requisite structural features for P-glycoprotein-mediated transport of a series of structurally related glucocorticoids (GCs). METHODS: Transport experiments were conducted in wild-type and stably transfected MDRI LLC-PK cell line. Transport efficiency (Teff = Peff, B-->A / Peff, A-->B) in both cell lines was compared as a measure of passive diffusion and...

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Identifiers

PMID: 14661924
DOI: 10.1023/b:pham.0000003377.39548.f6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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