Article
Combination vinorelbine and capecitabine for metastatic breast cancer using a non-body surface area dosing scheme.
Cancer chemotherapy and pharmacology - 1 Jul 2006
Schott Anne F, Rae James M, Griffith Kent A, Hayes Daniel F, Sterns Vered, Baker Laurence H
Abstract excerpt
PURPOSE: This study sought to determine the maximum tolerated dose of flat-dosed vinorelbine in combination with capecitabine in patients with metastatic breast cancer. At the time of study initiation, it was anticipated that vinorelbine would be developed as an oral capsule. A flat dosing scheme of both drugs was used to facilitate development of the oral regimen, and because neither drug's clearance is...
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