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Article

Dexamethasone as a probe for docetaxel clearance.

Cancer chemotherapy and pharmacology - 1 Sept 2004

Puisset Florent, Chatelut Etienne, Dalenc Florence, Busi Florent, Cresteil Thierry, Azéma Joëlle, Poublanc Muriel, Hennebelle Isabelle, Lafont Thierry, Chevreau Christine, Roché Henri

Abstract excerpt

PURPOSE: A pilot study was conducted in 23 patients in order to assess the correlation between docetaxel clearance (CL) and pharmacokinetics of dexamethasone. Dexamethasone is mainly 6-beta hydroxylated by CYP3A4, and is regularly used as standard docetaxel premedication. Genotyping of known functional single nucleotide polymorphism (SNP) of CYP3A5 (G22893A) and mdr-1 (G2677T, G2677A, and C3435T) have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15133628
DOI: 10.1007/s00280-004-0823-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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