Article
Hereditary nonpolyposis colorectal cancer identification and surveillance of high-risk families.
Clinics (Sao Paulo, Brazil) - 1 Jun 2005
Silva Roberta Vasconcelos E, Garicochea Bernardo, Cotti Guilherme, Maranho Isabel Cristina, Cutait Raul
Abstract excerpt
Hereditary nonpolyposis colorectal cancer is an autosomal dominant condition caused by highly penetrant gene mutations. It is characterized by increased susceptibility for a specific group of cancer, mainly colorectal cancer. The syndrome originates from the inheritance of mutations in DNA mismatch repair genes. The most commonly affected genes in hereditary nonpolyposis colorectal cancer are hMLH1 and hMSH2....
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