Article
Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis.
Gastroenterology - 1 Apr 1996
Vasen H F, Wijnen J T, Menko F H, Kleibeuker J H, Taal B G, Griffioen G, Nagengast F M, Meijers-Heijboer E H, Bertario L, Varesco L, Bisgaard M L, Mohr J, Fodde R, Khan P M
Abstract excerpt
BACKGROUND & AIMS: Hereditary nonpolyposis colorectal cancer is characterized by early-onset colorectal cancer and the occurrence of various other cancers. The recent isolation of four mismatch repair genes responsible for hereditary nonpolyposis colorectal cancer allows for the identification of carriers within affected families. The purpose of this study was to assess the age-specific cancer risk in a large...
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