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Article

UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver.

The Journal of pharmacology and experimental therapeutics - 1 Aug 2004

Court Michael H, Hao Qin, Krishnaswamy Soundararajan, Bekaii-Saab Tanios, Al-Rohaimi Abdul, von Moltke Lisa L, Greenblatt David J

Abstract excerpt

Oxazepam is a commonly used 1,4-benzodiazepine anxiolytic drug that is polymorphically metabolized in humans. However, the molecular basis for this phenomenon is currently unknown. We have previously shown that S-oxazepam glucuronide, the major oxazepam metabolite, is selectively formed by UDP-gl...

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PMID: 15044558
DOI: 10.1124/jpet.104.067660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15044558-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver.PMID 15044558Read ↗

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Evidence for oxazepam as an<i>in vivo</i>probe of UGT2B15: oxazepam clearance is reduced by<i>UGT2B15</i>D85Y polymorphism but unaffected by<i>UGT2B17</i>deletionSemantic proximity Read ↗

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