Article
Effects of CYP2C19*2 polymorphisms on the efficacy and safety of phenazepam in patients with anxiety disorder and comorbid alcohol use disorder.
Pharmacogenomics - 1 Jan 2020
Zastrozhin Michael S, Skryabin Valentin Y, Torrado Marco, Petrovna Anastasiya, Sorokin Alexander S, Grishina Elena A, Ryzhikova Kristina A, Bedina Inessa A, Buzik Oleg Z, Chumakov Egor M, Savchenko Ludmila M, Brun Evgeny A, Sychev Dmitry A
Abstract excerpt
Introduction: Phenazepam therapy can often be ineffective and some patients develop dose-related adverse drug reactions. Aim. The purpose of this research was to study the effect of the CYP2C19*2 (681G>A, rs4244285) in patients with anxiety disorders and alcohol dependence taking phenazepam therapy. Materials & methods: Patients (175 males, average age: 37.16 ± 7.84 years) received phenazepam in tablet form for 5...
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