Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Implication of UGT2B15 Genotype Polymorphism on Postoperative Anxiety Levels in Patients Receiving Lorazepam Premedication.

Anesthesia and analgesia - 1 Nov 2016

Mijderwijk Herjan, Klimek Markus, van Beek Stefan, van Schaik Ron H N, Duivenvoorden Hugo J, Stolker Robert Jan

Abstract excerpt

BACKGROUND: Lorazepam is used as premedication for its anxiolytic properties. The UGT2B15 genotype is of importance for the metabolism of lorazepam. The clinical effect of genetic polymorphisms in UGT2B15 genotype on the treatment of anxiety levels in same-day surgery patients receiving lorazepam, however, is unknown. METHODS: Three hundred ninety-eight same-day surgery patients of mixed sex (from a previous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Anxiety Agents
Share to Anxiety

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Double-Blind Method

Share to Genotype

Share to Glucuronosyltransferase

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 27622723
DOI: 10.1213/ANE.0000000000001508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Implication of UGT2B15 Genotype Polymorphism on Postoperative Anxiety Levels in Patients Receiving Lorazepam Premedication.PMID 27622723Read ↗

Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers.Semantic proximity Read ↗

UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver.Semantic proximity Read ↗

Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9.Semantic proximity Read ↗

Impact of clinical factors and UGT1A9 and CYP2B6 genotype on inter-individual differences in propofol pharmacokinetics.Semantic proximity Read ↗

Association of Polymorphisms in Pharmacogenetic Candidate Genes with Propofol Susceptibility.Semantic proximity Read ↗

Impact of the Cytochrome P450 2B6 (CYP2B6) Gene Polymorphism c.516G>T (rs3745274) on Propofol Dose Variability.Semantic proximity Read ↗

Evidence for oxazepam as an<i>in vivo</i>probe of UGT2B15: oxazepam clearance is reduced by<i>UGT2B15</i>D85Y polymorphism but unaffected by<i>UGT2B17</i>deletionSemantic proximity Read ↗

Relationship between the plasma fentanyl and serum 4β-hydroxycholesterol based on CYP3A5 genotype and gender in patients with cancer pain.Semantic proximity Read ↗

Effect of UGT2B7 -900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort.Semantic proximity Read ↗

ASP85TYR POLYMORPHISM IN THE UDP-GLUCURONOSYLTRANSFERASE (UGT) 2B15 GENE AND THE RISK OF PROSTATE CANCERSemantic proximity Read ↗

Association between serotonin transport polymorphisms and postdischarge nausea and vomiting in women following breast cancer surgery.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.