Impact of CYP2D6*2, CYP2D6*35, rs5758550, and related haplotypes on risperidone clearance in vivo.

doi:10.1007/s00228-024-03721-6

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Article

Impact of CYP2D62, CYP2D635, rs5758550, and related haplotypes on risperidone clearance in vivo.

European journal of clinical pharmacology - 1 Oct 2024

Størset Elisabet, Bråten Line Skute, Ingelman-Sundberg Magnus, Johansson Inger, Molden Espen, Kringen Marianne Kristiansen

Abstract excerpt

PURPOSE: The CYP2D6 gene exhibits significant polymorphism, contributing to variability in responses to drugs metabolized by CYP2D6. While CYP2D6*2 and CYP2D6*35 are presently designated as alleles encoding normal metabolism, this classification is based on moderate level evidence. Additionally, the role of the formerly called "enhancer" single nucleotide polymorphism (SNP) rs5758550 is unclear. In this study,...

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Identifiers

PMID: 38963454
DOI: 10.1007/s00228-024-03721-6
PMCID: PMC11393095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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