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Evidence for oxazepam as an<i>in vivo</i>probe of UGT2B15: oxazepam clearance is reduced by<i>UGT2B15</i>D85Y polymorphism but unaffected by<i>UGT2B17</i>deletion

7 Aug 2009

Abstract excerpt

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • UDP‐glucuronosyltransferase (UGT) 2B15 is a major drug glucuronidation enzyme expressed in human liver. • Oxazepam is an isoform‐selective probe drug that is being used for in vitro studies of UGT2B15. • The most common UGT2B15 missense polymorphisms (D85Y and K523T) are correlated with variable oxazepam glucuronidation in human liver bank samples. • UGT2B17 is also...

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PMID: 19916996
DOI: 10.1111/j.1365-2125.2009.03519.x

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Evidence for oxazepam as an<i>in vivo</i>probe of UGT2B15: oxazepam clearance is reduced by<i>UGT2B15</i>D85Y polymorphism but unaffected by<i>UGT2B17</i>deletionPMID 19916996Read ↗

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