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Article

Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain.

Biochemical and biophysical research communications - 29 Jul 2005

Melis Els, Moons Lieve, Arnout Jef, Hoylaerts Marc F, Collen Désiré, Carmeliet Peter, Dewerchin Mieke

Abstract excerpt

Mice with a targeted truncation in the gene encoding tissue factor of blood coagulation (TF) to eliminate the cytosolic domain and carrying a neo(R) cassette in intron 5 unexpectedly displayed severe spontaneous thrombosis in various vascular beds. Thrombosis was observed in heterozygous TF(+/neo) mice, causing death of over 50% of adults within 36 weeks of birth, and fulminantly exacerbating in pregnant females....

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Source

Identifiers

PMID: 15961065
DOI: 10.1016/j.bbrc.2005.05.144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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