Article
P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice.
Cancer investigation - 1 May 2012
Ramanathan Vigneshwaran, Jin Guangchun, Westphalen Christoph Benedikt, Whelan Ashley, Dubeykovskiy Alexander, Takaishi Shigeo, Wang Timothy C
Abstract excerpt
Transgenic mice overexpressing human progastrin (hGAS) show colonic crypt hyper-proliferation and elevated susceptibility to colon carcinogenesis. We aimed to investigate effects of p53 mutation on colon carcinogenesis in hGAS mice. We show that introducing a p53 gene mutation further increases progastrin dependent BrdU labeling and results in markedly elevated number of aberrant crypt foci (ACF) and colonic...
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