Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways

23 Jun 2016

Abstract excerpt

Clinical, epidemiological, and experimental evidence indicate that the insulin-like growth factors (IGFs) are important mediators in the biochemical chain of events that lead from a phenotypically normal to a neoplastic cell. The IGF1 receptor (IGF1R), which mediates the biological actions of IGF1 and IGF2, exhibits potent pro-survival and antiapoptotic activities. The IGF1R is highly expressed in most types of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Growth Hormone and Insulin-like Growth Factors
Share to Metabolism, Diabetes, and Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27446805
DOI: 10.3389/fonc.2016.00159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection PathwaysPMID 27446805Read ↗

Role of insulin-like growth factor 1 receptor signalling in cancerSemantic proximity Read ↗

Hallmarks of cancer: The insulin-like growth factors perspectiveSemantic proximity Read ↗

The Role of the IGF System in Cancer: From Basic to Clinical Studies and Clinical ApplicationsSemantic proximity Read ↗

Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapySemantic proximity Read ↗

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.Semantic proximity Read ↗

The role of the insulin-like growth factor-1 system in breast cancerSemantic proximity Read ↗

Insulin resistance and cancer: the role of insulin and IGFsSemantic proximity Read ↗

Targeting the IGF1 axis in cancer proliferationSemantic proximity Read ↗

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic GrowthSemantic proximity Read ↗

The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent InsightsSemantic proximity Read ↗

Drugging IGF-1R in cancer: New insights and emerging opportunitiesSemantic proximity Read ↗

Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and ChemoresistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.