Article
The insulin-like growth factors and insulin-signalling systems: an appealing target for breast cancer therapy?
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Jan 2000
Gray S G, Stenfeldt Mathiasen I, De Meyts P
Abstract excerpt
There is compelling evidence from epidemiological studies in humans, as well as in vitro and in vivo experimental observations including transgenic animal models, for a role of the IGF/insulin signalling system in cancer tumourigenesis. In this review focused on breast cancer, we review the experimental evidence, discuss the cellular and molecular mechanisms of tumourigenicity by the IGFs and insulin and various...
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