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Article

Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection.

Journal of virology - 1 Jul 2005

Koibuchi Tomohiko, Allen Todd M, Lichterfeld Mathias, Mui Stanley K, O'Sullivan Kristin M, Trocha Alicja, Kalams Spyros A, Johnson R Paul, Walker Bruce D

Abstract excerpt

Studies in acute human immunodeficiency virus type 1 (HIV-1) infection indicate viral evolution under CD8 T-cell immune selection pressure, but the effects of ongoing immune pressure on epitope evolution during chronic infection are not well described. In this study, we performed a detailed longitudinal analysis of viral sequence variation within persistently targeted cytotoxic T-lymphocyte (CTL) epitopes in two...

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Source

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Identifiers

PMID: 15956562
DOI: 10.1128/JVI.79.13.8171-8181.2005
PMCID: PMC1143727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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