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Article

Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants.

Nature immunology - 1 Mar 2005

Barouch Dan H, Powers Jennifer, Truitt Diana M, Kishko Michael G, Arthur Janelle C, Peyerl Fred W, Kuroda Marcelo J, Gorgone Darci A, Lifton Michelle A, Lord Carol I, Hirsch Vanessa M, Montefiori David C, Carville Angela, Mansfield Keith G, Kunstman Kevin J, Wolinsky Steven M, Letvin Norman L

Abstract excerpt

Viral escape from cytotoxic T lymphocytes (CTLs) can undermine immune control of human immunodeficiency virus 1. It is therefore important to assess the stability of viral mutations in CTL epitopes after transmission to naive hosts. Here we demonstrate the persistence of mutations in a dominant CTL epitope after transmission of simian immunodeficiency virus variants to major histocompatibility complex-matched...

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Share to Epitopes, T-Lymphocyte
Share to Immunodominant Epitopes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Major Histocompatibility Complex

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Share to Simian Acquired Immunodeficiency Syndrome

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Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 15685174
DOI: 10.1038/ni1167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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