Article
Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.
The Journal of experimental medicine - 15 Jan 2001
Altfeld M, Rosenberg E S, Shankarappa R, Mukherjee J S, Hecht F M, Eldridge R L, Addo M M, Poon S H, Phillips M N, Robbins G K, Sax P E, Boswell S, Kahn J O, Brander C, Goulder P J, Levy J A, Mullins J I, Walker B D
Abstract excerpt
Immune responses induced during the early stages of chronic viral infections are thought to influence disease outcome. Using HIV as a model, we examined virus-specific cytotoxic T lymphocytes (CTLs), T helper cells, and viral genetic diversity in relation to duration of infection and subsequent response to antiviral therapy. Individuals with acute HIV-1 infection treated before seroconversion had weaker CTL...
Topics
- Acute Disease
- Amino Acid Sequence
- Antiretroviral Therapy, Highly Active
- Base Sequence
- Cohort Studies
- DNA Primers
- Epitopes
- Female
- Genetic Variation
- HIV Infections