Article
A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects.
American journal of physiology. Endocrinology and metabolism - 1 Oct 2007
Weickert Martin O, Loeffelholz Christian V, Roden Michael, Chandramouli Visvanathan, Brehm Attila, Nowotny Peter, Osterhoff Martin A, Isken Frank, Spranger Jochen, Landau Bernard R, Pfeiffer Andreas F H, Möhlig Matthias
Abstract excerpt
Liver fatty acid-binding protein (L-FABP) is a highly conserved key factor in lipid metabolism. Amino acid replacements in L-FABP might alter its function and thereby affect glucose metabolism in lipid-exposed subjects, as indicated by studies in L-FABP knockout mice. Amino acid replacements in L-FABP were investigated in a cohort of 1,453 Caucasian subjects. Endogenous glucose production (EGP), gluconeogenesis,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.