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Article

Origin, diversification and substrate specificity in the family of NCS1/FUR transporters.

Molecular microbiology - 1 Jun 2015

Krypotou Emilia, Evangelidis Thomas, Bobonis Jacob, Pittis Alexandros A, Gabaldón Toni, Scazzocchio Claudio, Mikros Emmanuel, Diallinas George

Abstract excerpt

NCS1 proteins are H(+)/Na(+) symporters specific for the uptake of purines, pyrimidines and related metabolites. In this article, we study the origin, diversification and substrate specificity of fungal NCS1 transporters. We show that the two fungal NCS1 sub-families, Fur and Fcy, and plant homologues originate through independent horizontal transfers from prokaryotes and that expansion by gene duplication led to...

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Identifiers

PMID: 25712422
DOI: 10.1111/mmi.12982

Genes

NCS1

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