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Congenital heart defects and genetic variants in the methylenetetrahydroflate reductase gene

10 Jun 2005

Abstract excerpt

BACKGROUND: Most non-syndromic congenital heart defects (CHD) are caused by a complex interaction between maternal lifestyle factors, environmental exposures, and maternal and fetal genetic variants. Maternal periconceptional intake of folic acid containing vitamin supplements is reported to decrease the risk of CHD. The 677C-->T and 1298A-->C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene...

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Identifiers

PMID: 15951337
DOI: 10.1136/jmg.2005.032656

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