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Article

Methylenetetrahydrofolate reductase C677T polymorphism and congenital heart disease: a meta-analysis.

Clinical chemistry and laboratory medicine - 1 Dec 2011

Nie Yu, Gu Haiyong, Gong Jie, Wang Jue, Gong Dingxu, Cong Xiangfeng, Chen Xi, Hu Shengshou

Abstract excerpt

BACKGROUND: As a key enzyme in folate metabolism, 5,10- methylenetetrahydrofolate reductase (MTHFR) regulates the homeostasis between DNA synthesis and methylation. Data on the association between the MTHFR C677T polymorphism and congenital heart disease (CHD) are conflicting. METHODS: To assess the relationship between the MTHFR 677TT genotype and the risk of CHD, we performed a metaanalysis, searching in Pubmed...

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Source

Identifiers

PMID: 21793799
DOI: 10.1515/CCLM.2011.673

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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