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Article

Methylenetetrahydrofolate reductase C677T polymorphism and congenital heart disease: a meta-analysis.

Clinical chemistry and laboratory medicine - 1 Dec 2011

Nie Yu, Gu Haiyong, Gong Jie, Wang Jue, Gong Dingxu, Cong Xiangfeng, Chen Xi, Hu Shengshou

Abstract excerpt

BACKGROUND: As a key enzyme in folate metabolism, 5,10- methylenetetrahydrofolate reductase (MTHFR) regulates the homeostasis between DNA synthesis and methylation. Data on the association between the MTHFR C677T polymorphism and congenital heart disease (CHD) are conflicting. METHODS: To assess the relationship between the MTHFR 677TT genotype and the risk of CHD, we performed a metaanalysis, searching in Pubmed...

Topics

Alleles
Amino Acid Substitution
Databases, Factual
Genotype
Heart Defects, Congenital
Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Odds Ratio
Polymorphism, Genetic
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21793799
DOI: 10.1515/CCLM.2011.673

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21793799-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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