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Article

The MTHFR 677C->T polymorphism and the risk of congenital heart defects: a literature review and meta-analysis.

QJM : monthly journal of the Association of Physicians - 1 Dec 2007

van Beynum I M, den Heijer M, Blom H J, Kapusta L

Abstract excerpt

BACKGROUND: Periconceptional folic acid supplementation may protect against congenital heart defects (CHDs). Identification of candidate genes in folate metabolism has suggested that the 677C-->T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene may be particularly associated with the risk of CHDs. AIM: To assess the relationship between MTHFR 677C-->T and CHDs by literature review and...

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Source

Identifiers

PMID: 17965089
DOI: 10.1093/qjmed/hcm094

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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