Article
Meta analysis of the association between MTHFR C677T polymorphism and the risk of congenital heart defects.
Annals of human genetics - 1 Jan 2012
Yin Meng, Dong Lingyan, Zheng Jinghao, Zhang Haibo, Liu Jinfen, Xu Zhiwei
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) polymorphism C667T has been associated with congenital malformation; this common missense mutation in the MTHFR gene may reduce enzymatic action, and may be involved in the etiology of congenital heart defects (CHD). The aim of this study was to investi...
Topics
- Adult
- Case-Control Studies
- Child
- Child, Preschool
- Female
- Genetic Predisposition to Disease
- Heart Defects, Congenital
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Mutation, Missense
- Polymorphism, Genetic
- Risk