Article
Association between C677T polymorphism of methylene tetrahydrofolate reductase and congenital heart disease: meta-analysis of 7697 cases and 13,125 controls.
Circulation. Cardiovascular genetics - 1 Aug 2013
Mamasoula Chrysovalanto, Prentice R Reid, Pierscionek Tomasz, Pangilinan Faith, Mills James L, Druschel Charlotte, Pass Kenneth, Russell Mark W, Hall Darroch, Töpf Ana, Brown Danielle L, Zelenika Diana, Bentham Jamie, Cosgrove Catherine, Bhattacharya Shoumo, Riveron Javier Granados, Setchfield Kerry, Brook J David, Bu'Lock Frances A, Thornborough Chris, Rahman Thahira J, Doza Julian Palomino, Tan Huay L, O'Sullivan John, Stuart A Graham, Blue Gillian, Winlaw David, Postma Alex V, Mulder Barbara J M, Zwinderman Aelko H, van Engelen Klaartje, Moorman Antoon F M, Rauch Anita, Gewillig Marc, Breckpot Jeroen, Devriendt Koen, Lathrop G Mark, Farrall Martin, Goodship Judith A, Cordell Heather J, Brody Lawrence C, Keavney Bernard D
Abstract excerpt
BACKGROUND: Association between the C677T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene and congenital heart disease (CHD) is contentious. METHODS AND RESULTS: We compared genotypes between CHD cases and controls and between mothers of CHD cases and controls. We placed our...
Topics
- Alleles
- Cohort Studies
- Databases, Genetic
- Folic Acid
- Genetic Predisposition to Disease
- Genotype