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Article

MTHFR C677T polymorphism and risk of congenital heart defects: evidence from 29 case-control and TDT studies.

PloS one - 1 Jan 2013

Wang Wei, Wang Yujia, Gong Fangqi, Zhu Weihua, Fu Songling

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme for folate metabolism in humans; it is encoded by the MTHFR gene. Several studies have assessed the association between MTHFR C677T polymorphism and the risk of congenital heart defects (CHDs), while the results were inconsistent. METHODS AND FINDINGS: Multiple electronic databases were searched to identify relevant studies published...

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Source

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Identifiers

PMID: 23536781
DOI: 10.1371/journal.pone.0058041
PMCID: PMC3594197

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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