Article
Lack of KRAS gene mutations in chronic myeloid leukemia in Iran.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014
Kooshyar Mohammad Mahdi, Ayatollahi Hossein, Keramati Mohammad Reza, Sadeghian Mohammad Hadi, Miri Mohsen, Sheikhi Maryam
Abstract excerpt
BACKGROUND: The single most common proto-oncogene change in human neoplasms is a point mutation in RAS genes. A wide range of variation in frequency of KRAS mutations has been seen in hematologic malignancies. Despite this, RAS roles in leukemogenesis remain unclear. The frequency of KRAS mutations in CML has been reported to be between zero an 10%. Many attempts have been done to develop an anti-RAS drug as a...
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