Article
RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi.
Molecular cell - 5 May 2006
Lee Donghan, Walsh Joseph D, Mikhailenko Irina, Yu Ping, Migliorini Molly, Wu Yibing, Krueger Susan, Curtis Joseph E, Harris Bradley, Lockett Stephen, Blacklow Steve C, Strickland Dudley K, Wang Yun-Xing
Abstract excerpt
The receptor associated protein (RAP) is an antagonist and molecular chaperone that binds tightly to low-density lipoprotein receptor family members in the endoplasmic reticulum (ER). After escorting these receptors to the Golgi, RAP dissociates from the receptors. The molecular mechanism of the dissociation has been unknown until now. The solution structure of RAP-D3 domain presented here reveals a striking...
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