Article
Familial hypercholesterolemia: dissection of a receptor disease.
Zeitschrift fur Kardiologie - 1 Jan 1990
Schneider W J
Abstract excerpt
In 1973, studies with cultured human fibroblasts by Brown, Goldstein, and colleagues showed that receptor-mediated endocytosis of low-density lipoprotein (LDL) is the regulatory principle in cellular cholesterol homeostasis. The complete sequence of metabolic events associated with the binding, u...
Topics
- Animals
- Humans
- Hyperlipoproteinemia Type II
- Lipoproteins, LDL
- Mutation
- Receptors, LDL