Article
Structure of the LDL receptor extracellular domain at endosomal pH.
Science (New York, N.Y.) - 20 Dec 2002
Rudenko Gabby, Henry Lisa, Henderson Keith, Ichtchenko Konstantin, Brown Michael S, Goldstein Joseph L, Deisenhofer Johann
Abstract excerpt
The low-density lipoprotein receptor mediates cholesterol homeostasis through endocytosis of lipoproteins. It discharges its ligand in the endosome at pH < 6. In the crystal structure at pH = 5.3, the ligand-binding domain (modules R2 to R7) folds back as an arc over the epidermal growth factor precursor homology domain (the modules A, B, beta propeller, and C). The modules R4 and R5, which are critical for...
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