Low-density lipoprotein receptor--its structure, function, and mutations.

doi:10.1055/s-2004-822993

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Article

Low-density lipoprotein receptor--its structure, function, and mutations.

Seminars in vascular medicine - 1 Feb 2004

Defesche Joep C

Abstract excerpt

Uptake of cholesterol, mediated by the low-density lipoprotein (LDL)-receptor, plays a crucial role in lipoprotein metabolism. The LDL-receptor is responsible for the binding and subsequent cellular uptake of apolipoprotein B- and E-containing lipoproteins. To accomplish this, the receptor has to be transported from the site of synthesis, the membranes of the rough endoplasmatic reticulum (ER), through the Golgi...

Topics

Genotype
Humans
Mutation
Receptors, LDL

Source

Open in PubMed

Identifiers

PMID: 15199428
DOI: 10.1055/s-2004-822993

Provenance

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