Article
Low-density lipoprotein receptor structure and folding.
Cellular and molecular life sciences : CMLS - 1 Oct 2004
Gent J, Braakman I
Abstract excerpt
The endoplasmic reticulum (ER) is a major cellular 'production factory' for many membrane and soluble proteins. A quality control system ensures that only correctly folded and assembled proteins leave the compartment. The low-density lipoprotein receptor (LDLR) is the prototype of a large family of structurally homologous cell surface receptors, which fold in the ER and function as endocytic and signaling...
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