Article
[Biological impact of the COOH-terminal 40 amino acid deletions of hepatitis B virus X protein in hepatocellular carcinoma cells].
Zhonghua yi xue za zhi - 30 Mar 2005
Liu Xiao-Hong, Lin Jing, Cao Xiao-Zhe, Zheng Jian-Ming, Chen Ying, Zhu Ming-Hua
Abstract excerpt
OBJECTIVE: To investigate the biological impact of the wild type hepatitis B virus X protein (HBx) and HBx3'-40, an engineered deletion mutant of HBx lacking the last 40 C-terminal amino acids and a transcriptional transactivator on hepatoma cells. METHODS: Human hepatocellular cells of the lines Huh7 and SMMC-7721 were transfected with HBx3'-40 or HBx constructs. The integration of the plasmid DNA and the...
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